Developing an interactive writing tool for business law students

Students&rsquo; performance in assessment tasks requiring logical written answers to case study problems can be adversely affected by difficulties in constructing a full length, logical written argument that demonstrates understanding to the level expected. This paper describes a teaching and learning tool developed to assist students in constructing logical full-length answers to given problems, using individual understanding of underlying concepts and their application. The tool allows students to see their thoughts and reasoning written into full-length answers of different styles. Developed initially for Business law students, this Answer Styles tool has scope to assist students&rsquo; writing in many disciplines.</div

Nanoliter contact angle probes tumor angiogenic ligand-receptor protein interactions

Any molecular recognition reaction supported by a solid-phase drives a specific change of the solid-solution interfacial tension. Sessile Contact Angle (CA) experiments can be readily used to track this thermodynamic parameter, prompting this well-known technique to be reinvented as an alternative, easy-access and label-free way to probe and study molecular recognition events. Here we deploy this technique, renamed for this application CONAMORE (CONtact Angle MOlecular REcognition), to study the interaction of the tumor-derived pro-angiogenic vascular endothelial growth factor-A (VEGF-A) with the extracellular domain of its receptor VEGFR2. We show that CONAMORE recognizes the high affinity binding of VEGF-A at nanomolar concentrations to surface-immobilized VEGFR2 regardless of the presence of a ten folds excess of a non specific interacting protein, and that it further proofs its specificity and reliability on competitive binding experiments involving neutralizing anti-VEGF-A antibodies. Finally, CONAMORE shows the outstanding capability to detect the specific interaction between VEGFR2 and low molecular weight ligands, such as Cyclo-VEGI, a VEGFR2 antagonist cyclo-peptide, that weights about 2 kDa

XMM-Newton observation of MACHO 104.20906.960: a dwarf nova candidate with a 2 h period

The binaries known as cataclysmic variables are particular binary systems in which the primary star (a white dwarf) accretes material from a secondary via Roche-lobe mechanism. Usually, these objects have orbital period of a few hours so that a detailed temporal analysis can be performed. Here, we present Chandra ${\it XMM}$-Newton observations of a dwarf nova candidate identified in the past by optical observations towards the galactic Bulge and labeled as MACHO 104.20906.960. After a spectral analysis, we used the Lomb-Scargle technique for the period search and evaluated the confidence level using Monte-Carlo simulations. In this case, we found that the $X$-ray source shows a period of $2.03_{-0.07}^{+0.09}$ hours (3$\sigma$ error) so that it is most likely a system of interacting objects. The modulation of the signal was found with a confidence level of $>$99%. The spectrum can be described by a two thermal plasma components with X-ray flux in the 0.3--10 keV energy band of $1.77_{-0.19}^{+0.16}\times10^{-13}$ erg s$^{-1}$ cm$^{-2}$. We find that the distance of the source is approximately 1 kpc thus corresponding to a luminosity $L_{X}\simeq 2\times 10^{31}$ erg s$^{-1}$.Comment: 2008, in press on New Astronomy, (http://www.elsevier.com/wps/find/journaldescription.cws_home/601274/description#description); XMM-Newton observation of MACHO 104.20906.960: a dwarf nova candidate with a 2 h perio

The YSO Population in the Vela-D Molecular Cloud

We investigate the young stellar population in the Vela Molecular Ridge, Cloud-D (VMR-D), a star forming (SF) region observed by both Spitzer/NASA and Herschel/ESA space telescope. The point source, band-merged, Spitzer-IRAC catalog complemented with MIPS photometry previously obtained is used to search for candidate young stellar objects (YSO), also including sources detected in less than four IRAC bands. Bona fide YSO are selected by using appropriate color-color and color-magnitude criteria aimed to exclude both Galatic and extragalactic contaminants. The derived star formation rate and efficiency are compared with the same quantities characterizing other SF clouds. Additional photometric data, spanning from the near-IR to the submillimeter, are used to evaluate both bolometric luminosity and temperature for 33 YSOs located in a region of the cloud observed by both Spitzer and Herschel. The luminosity-temperature diagram suggests that some of these sources are representative of Class 0 objects with bolometric temperatures below 70 K and luminosities of the order of the solar luminosity. Far IR observations from the Herschel/Hi-GAL key project for a survey of the Galactic plane are also used to obtain a band-merged photometric catalog of Herschel sources aimed to independently search for protostars. We find 122 Herschel cores located on the molecular cloud, 30 of which are protostellar and 92 starless. The global protostellar luminosity function is obtained by merging the Spitzer and Herschel protostars. Considering that 10 protostars are found in both Spitzer and Herschel list it follows that in the investigated region we find 53 protostars and that the Spitzer selected protostars account for approximately two-thirds of the total.Comment: 40 pages, 12 figures, accepted for publication in Ap

The X-ray eclipse of the dwarf nova HT CAS observed by the XMM-Newton satellite: spectral and timing analysis

A cataclysmic variable is a binary system consisting of a white dwarf that accretes material from a secondary object via the Roche-lobe mechanism. In the case of long enough observation, a detailed temporal analysis can be performed, allowing the physical properties of the binary system to be determined. We present an XMM-Newton observation of the dwarf nova HT Cas acquired to resolve the binary system eclipses and constrain the origin of the X-rays observed. We also compare our results with previous ROSAT and ASCA data. After the spectral analysis of the three EPIC camera signals, the observed X-ray light curve was studied with well known techniques and the eclipse contact points obtained. The X-ray spectrum can be described by thermal bremsstrahlung of temperature $kT_1=6.89 \pm 0.23$ keV plus a black-body component (upper limit) with temperature $kT_2=30_{-6}^{+8}$ eV. Neglecting the black-body, the bolometric absorption corrected flux is $F^{\rm{Bol}}=(6.5\pm 0.1)\times10^{-12}$ erg s$^{-1}$ cm$^{-2}$, which, for a distance of HT Cas of 131 pc, corresponds to a bolometric luminosity of $(1.33\pm 0.02)\times10^{31}$ erg s$^{-1}$. The study of the eclipse in the EPIC light curve permits us to constrain the size and location of the X-ray emitting region, which turns out to be close to the white dwarf radius. We measure an X-ray eclipse somewhat smaller (but only at a level of $\simeq 1.5 \sigma$) than the corresponding optical one. If this is the case, we have possibly identified the signature of either high latitude emission or a layer of X-ray emitting material partially obscured by an accretion disk.Comment: Accepted for publication on Astronomy and Astrophysics, 200

High Aspect Ratio Silicon Wire Array Photoelectrochemical Cells

In an effort to develop low-cost solar energy conversion techniques, high uniformity vertically oriented silicon wire arrays have been fabricated. These arrays, which allow for radial diffusion of minority charge carriers, have been measured in a photoelectrochemical cell. Large photovoltages (∼400 mV) have been measured, and these values are significantly greater than those obtained from the substrate alone. Additionally, the wire array samples displayed much higher current densities than the underlying substrate, demonstrating that significant energy conversion was occurring due to the absorption and charge-carrier transport in the vertically aligned Si wires. This method therefore represents a step toward the use of collection-limited semiconductor materials in a wire array format in macroscopic solar cell devices

22q11.2 Deletion Syndrome. Impact of Genetics in the Treatment of Conotruncal Heart Defects

Congenital heart diseases represent one of the hallmarks of 22q11.2 deletion syndrome. In particular, conotruncal heart defects are the most frequent cardiac malformations and are often associated with other specific additional cardiovascular anomalies. These findings, together with extracardiac manifestations, may affect perioperative management and influence clinical and surgical outcome. Over the past decades, advances in genetic and clinical diagnosis and surgical treatment have led to increased survival of these patients and to progressive improvements in postoperative outcome. Several studies have investigated long-term follow-up and results of cardiac surgery in this syndrome. The aim of our review is to examine the current literature data regarding cardiac outcome and surgical prognosis of patients with 22q11.2 deletion syndrome. We thoroughly evaluate the most frequent conotruncal heart defects associated with this syndrome, such as tetralogy of Fallot, pulmonary atresia with major aortopulmonary collateral arteries, aortic arch interruption, and truncus arteriosus, highlighting the impact of genetic aspects, comorbidities, and anatomical features on cardiac surgical treatment

Energy-Conversion Properties of Vapor-Liquid-Solid–Grown Silicon Wire-Array Photocathodes

Silicon wire arrays, though attractive materials for use in photovoltaics and as photocathodes for hydrogen generation, have to date exhibited poor performance. Using a copper-catalyzed, vapor-liquid-solid–growth process, SiCl_4 and BCl_3 were used to grow ordered arrays of crystalline p-type silicon (p-Si) microwires on p^+-Si(111) substrates. When these wire arrays were used as photocathodes in contact with an aqueous methyl viologen^(2+/+) electrolyte, energy-conversion efficiencies of up to 3% were observed for monochromatic 808-nanometer light at fluxes comparable to solar illumination, despite an external quantum yield at short circuit of only 0.2. Internal quantum yields were at least 0.7, demonstrating that the measured photocurrents were limited by light absorption in the wire arrays, which filled only 4% of the incident optical plane in our test devices. The inherent performance of these wires thus conceptually allows the development of efficient photovoltaic and photoelectrochemical energy-conversion devices based on a radial junction platform

Entanglement of electrons in interacting molecules

Quantum entanglement is a concept commonly used with reference to the existence of certain correlations in quantum systems that have no classical interpretation. It is a useful resource to enhance the mutual information of memory channels or to accelerate some quantum processes as, for example, the factorization in Shor's Algorithm. Moreover, entanglement is a physical observable directly measured by the von Neumann entropy of the system. We have used this concept in order to give a physical meaning to the electron correlation energy in systems of interacting electrons. The electronic correlation is not directly observable, since it is defined as the difference between the exact ground state energy of the many--electrons Schroedinger equation and the Hartree--Fock energy. We have calculated the correlation energy and compared with the entanglement, as functions of the nucleus--nucleus separation using, for the hydrogen molecule, the Configuration Interaction method. Then, in the same spirit, we have analyzed a dimer of ethylene, which represents the simplest organic conjugate system, changing the relative orientation and distance of the molecules, in order to obtain the configuration corresponding to maximum entanglement.Comment: 15 pages, 7 figures, standard late